Gas chromatographic-mass spectrometric isotope dilution determination of N,N-dimethyltryptamine concentrations in normals and psychiatric patients

@article{Wyatt2004GasCS,
  title={Gas chromatographic-mass spectrometric isotope dilution determination of N,N-dimethyltryptamine concentrations in normals and psychiatric patients},
  author={Richard Jed Wyatt and Lewis R. Mandel and H S Ahn and Robert W. Walker and W. J. A. Vanden. Heuvel},
  journal={Psychopharmacologia},
  year={2004},
  volume={31},
  pages={265-270}
}
A gas chromatographic-mass spectrometric determination of the plasma N,N-dimethyltryptamine concentration from normals and psychiatric patients revealed that within the limit of sensitivity of the assay (0.5–1.8 ng/ml of plasma), there was no difference amongst normals, patients with psychotic depression, acute and chronic schizophrenia. 
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References

SHOWING 1-10 OF 23 REFERENCES
Gas chromatographic-mass spectrometric isotope dilution assay for N,N-dimethyltryptamine in human plasma.
TLDR
An isotope dilution assay for the determination of N,N-dimethyltryptamine in human plasma has been developed and serves as an internal standard in a gas chromatographic-mass spectrometric analysis of the final isolate. Expand
Identification of N,N-dimethyltryptamine as the product of an in vitro enzymic methylation.
Abstract Thin-layer chromatography, reverse isotope dilution assay, and combined gas-liquid chromatography-mass spectrometry have demonstrated that an enzyme obtained from human lung catalyzes the inExpand
Tryptamine, N,N-Dimethyltryptamine, N,N-Dimethyl-5-hydroxytryptamine and 5-Methoxytryptamine in Human Blood and Urine
TLDR
5-Methoxytryptamine has been found in the urine of patients with rheumatic fever, and that in an order of magnitude of 30–210 µg/24 h, while N,N-dimethyl-5-hydroxytryptamine was still not demonstrated in blood. Expand
Psychotomimetic N-Methylated Tryptamines: Formation in Brain in vivo and in vitro
TLDR
An enzyme that converts tryptamine and N-methyl-tryptamine to N- methyl-and dimethyltryptamine was found to be present in rat and human brain. Expand
A dimethyltryptamine-forming enzyme in human blood.
TLDR
An enzyme capable of forming the hallucinogen dimethyltryptamine was found in human red blood cells, plasma, and platelets and was higher in psychotic subjects than in nonpsychotics and was apparently related to the presence of a dialyzable inhibitor in the normal subjects. Expand
Indole(ethyl)amine N-methyltransferase in human brain.
TLDR
Preliminary evidence gathered in laboratories from rats infused intraventricularly with bufotenin has suggested that this substance is at least as potent as its powerfully hallucinogenic 5-methoxy congener, and may not easily cross the blood-brain barrier. Expand
Reduced Monoamine Oxidase Activity in Blood Platelets from Schizophrenic Patients
TLDR
Direct examination of cellular MAO in schizophrenic patients might be of interest and the evidence that MAO-inhibiting drugs may on occasion contribute to exacerbations of psychotic behaviour is suggested. Expand
Behavioral Changes of Chronic Schizophrenic Patients Given L-5-Hydroxytryptophan
Oral administration of the serotonin precursor L-5-hydroxytryptophan with a peripheral decarboxylase inhibitor produced Mild to moderate improvement in six of seven chronic undifferentiatedExpand
Reduced Monoamine Oxidase Activity in Platelets: A Possible Genetic Marker for Vulnerability to Schizophrenia
TLDR
The data suggest, but do not prove, that reduced platelet monoamine oxidase activity may provide a genetic marker for vulnerability to schizophrenia. Expand
Dimethyltryptamin: Its metabolism in man; the relation of its psychotic effect to the serotonin metabolism
Es wird festgestellt, dass Dimethyltryptamin — bei normalen Versuchspersonen — eine dem Meskalin und dem LSD-25 ähnliche psychotische Wirkung hat. Der durch Dimethyltryptamin induzierte ZustandExpand
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