Gas chromatographic-mass spectrometric isotope dilution determination of N,N-dimethyltryptamine concentrations in normals and psychiatric patients

  title={Gas chromatographic-mass spectrometric isotope dilution determination of N,N-dimethyltryptamine concentrations in normals and psychiatric patients},
  author={Richard Jed Wyatt and Lewis R. Mandel and H S Ahn and Robert W. Walker and W. J. A. Vanden. Heuvel},
A gas chromatographic-mass spectrometric determination of the plasma N,N-dimethyltryptamine concentration from normals and psychiatric patients revealed that within the limit of sensitivity of the assay (0.5–1.8 ng/ml of plasma), there was no difference amongst normals, patients with psychotic depression, acute and chronic schizophrenia. 
Blood and urine levels of N,N-dimethyltryptamine following administration of psychoactive dosages to human subjects
Psychoactive doses of the hallucinogen N,N-dimethyltryptamine were administered intramuscularly to 11 normal subjects and the blood DMT concentrations had a very similar time course o the subjectively reported “high”. Expand
Dimethyltryptamine levels in blood of schizophrenic patients and control subjects
The results appear to suggest that the mean DMT level was higher in the total patient group, those patients with acute psychosis, female patients and patients with suspiciousness scores on the BPRS of 4 or over, but differences were not statistically significant. Expand
Dimethyltryptamine: Possible Endogenous Ligand of the Sigma-1 Receptor?
[1] Manske RHF (1931) A synthesis of the methyltryptamines and some derivatives. Can J Res 5: 592–600 [2] Szára S (1956) Dimethyltryptamin: its metabolism in man; the relation to its psychotic effectExpand
A critical review of reports of endogenous psychedelic N, N-dimethyltryptamines in humans: 1955-2010.
A critical review of 69 published studies reporting the detection or detection and quantitation of these compounds in human body fluids addresses the methods applied and the criteria used in the determination of the presence of DMT, MDMT, and HDMT. Expand
The psychedelic model of schizophrenia: the case of N,N-dimethyltryptamine.
The authors review the research on DMT as a possible "schizotoxin" and conclude that more data are necessary before the validity of this theory can be determined. Expand
Elevated urine levels of bufotenine in patients with autistic spectrum disorders and schizophrenia.
Elevated urine levels of the endogeneous psychotomimetic molecule bufotenine may play a role in ASD and schizophrenia, and can be correlated with hyperactivity scores in autism. Expand
Decreased platelet monoamine oxidase activity in chronic schizophrenia, shown with novel substrates.
The value of Km/Vmax was similar for schizophrencis and normal persons when DA, 5-HT, and DMT were used as substrates, which may indicate that "uncompetitive" inhibition is responsible for the observed decrease in activity among chronic schizophrenics. Expand
Building Alien Worlds — The Neuropsychological and Evolutionary Implications of the Astonishing Psychoactive Eff ects of N , N-Dimethyltryptamine ( DMT )
Arguably the most remarkable property of the human brain is its ability to construct the world that appears to consciousness. The brain is capable of building worlds during waking life, but also inExpand
Autistic Spectrum Disorders and Schizophrenia
This chapter will review some of the recent advances in the current understanding of autism spectrum disorders and clarify the similarities and differences in presentation between autism and childhood onset schizophrenia. Expand
Ayahuasca : liane de l'âme, chamanes et soumission chimique
Les plantes hallucinogenes sont utilisees dans les societes primitives depuis des siecles, mais jusqu'a maintenant leur usage se limitait a quelques individus chamanes, medecins-sorciers, etc... lorsExpand


Gas chromatographic-mass spectrometric isotope dilution assay for N,N-dimethyltryptamine in human plasma.
An isotope dilution assay for the determination of N,N-dimethyltryptamine in human plasma has been developed and serves as an internal standard in a gas chromatographic-mass spectrometric analysis of the final isolate. Expand
Identification of N,N-dimethyltryptamine as the product of an in vitro enzymic methylation.
Abstract Thin-layer chromatography, reverse isotope dilution assay, and combined gas-liquid chromatography-mass spectrometry have demonstrated that an enzyme obtained from human lung catalyzes the inExpand
Tryptamine, N,N-Dimethyltryptamine, N,N-Dimethyl-5-hydroxytryptamine and 5-Methoxytryptamine in Human Blood and Urine
5-Methoxytryptamine has been found in the urine of patients with rheumatic fever, and that in an order of magnitude of 30–210 µg/24 h, while N,N-dimethyl-5-hydroxytryptamine was still not demonstrated in blood. Expand
Psychotomimetic N-Methylated Tryptamines: Formation in Brain in vivo and in vitro
An enzyme that converts tryptamine and N-methyl-tryptamine to N- methyl-and dimethyltryptamine was found to be present in rat and human brain. Expand
A dimethyltryptamine-forming enzyme in human blood.
An enzyme capable of forming the hallucinogen dimethyltryptamine was found in human red blood cells, plasma, and platelets and was higher in psychotic subjects than in nonpsychotics and was apparently related to the presence of a dialyzable inhibitor in the normal subjects. Expand
Indole(ethyl)amine N-methyltransferase in human brain.
Preliminary evidence gathered in laboratories from rats infused intraventricularly with bufotenin has suggested that this substance is at least as potent as its powerfully hallucinogenic 5-methoxy congener, and may not easily cross the blood-brain barrier. Expand
Reduced Monoamine Oxidase Activity in Blood Platelets from Schizophrenic Patients
Direct examination of cellular MAO in schizophrenic patients might be of interest and the evidence that MAO-inhibiting drugs may on occasion contribute to exacerbations of psychotic behaviour is suggested. Expand
Behavioral Changes of Chronic Schizophrenic Patients Given L-5-Hydroxytryptophan
Oral administration of the serotonin precursor L-5-hydroxytryptophan with a peripheral decarboxylase inhibitor produced Mild to moderate improvement in six of seven chronic undifferentiatedExpand
Reduced Monoamine Oxidase Activity in Platelets: A Possible Genetic Marker for Vulnerability to Schizophrenia
The data suggest, but do not prove, that reduced platelet monoamine oxidase activity may provide a genetic marker for vulnerability to schizophrenia. Expand
Dimethyltryptamin: Its metabolism in man; the relation of its psychotic effect to the serotonin metabolism
Es wird festgestellt, dass Dimethyltryptamin — bei normalen Versuchspersonen — eine dem Meskalin und dem LSD-25 ähnliche psychotische Wirkung hat. Der durch Dimethyltryptamin induzierte ZustandExpand