Gas chromatographic determination of cocaine and its metabolites in blood and urine from cocaine users in northwestern Spain.

@article{Fernndez2004GasCD,
  title={Gas chromatographic determination of cocaine and its metabolites in blood and urine from cocaine users in northwestern Spain.},
  author={Purificaci{\'o}n Fern{\'a}ndez and Louis Bujan and Ana Mar{\'i}a Bermejo and Mar{\'i}a Jes{\'u}s Tabernero},
  journal={Journal of applied toxicology : JAT},
  year={2004},
  volume={24 4},
  pages={283-7}
}
A gas chromatographic method with fl ame ionization detection (GC/FID) was developed for the determination of cocaine and its metabolites in blood and urine samples from cocaine users in Northwestern Spain. After a solid-phase extraction with Bond Elut Certify cartridges and a derivatization with bis-trimethylsilyltrifluoroacetamide-trimethylchlorosilane (1%), calibration curves were constructed over 0.4-4 micro g ml(-1) for urine and 0.1-2 micro g ml(-1) for blood, using proadifen as the… CONTINUE READING