Garlic attenuates nitric oxide production in rat cardiac myocytes through inhibition of inducible nitric oxide synthase and the arginine transporter CAT-2 (cationic amino acid transporter-2).

@article{Schwartz2002GarlicAN,
  title={Garlic attenuates nitric oxide production in rat cardiac myocytes through inhibition of inducible nitric oxide synthase and the arginine transporter CAT-2 (cationic amino acid transporter-2).},
  author={Idit Feenberg Schwartz and Rami Hershkovitz and Adrian Iaina and Ehud Gnessin and Yoram Wollman and Tamara Chernichowski and Miriam Blum and Yoram Levo and Doron Schwartz},
  journal={Clinical science},
  year={2002},
  volume={102 5},
  pages={
          487-93
        }
}
It is now accepted that allicin, the main biologically active compound in garlic, exhibits antioxidant activity. The present study was designed to test the hypothesis that the antioxidant activity of garlic can be partially attributed to the inhibition of nitric oxide (NO) production by cytokine-induced NO synthase (iNOS). Cardiac myocytes cultured from neonatal Wistar rats were stimulated by lipopolysaccharide (LPS) and incubated for 24 h with various concentrations of allicin. This resulted… CONTINUE READING

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