Garlic and Onions: Their Cancer Prevention Properties

@article{Nicastro2015GarlicAO,
  title={Garlic and Onions: Their Cancer Prevention Properties},
  author={Holly L Nicastro and Sharon A Ross and John A. Milner},
  journal={Cancer Prevention Research},
  year={2015},
  volume={8},
  pages={181 - 189}
}
The Allium genus includes garlic, onions, shallots, leeks, and chives. These vegetables are popular in cuisines worldwide and are valued for their potential medicinal properties. Epidemiologic studies, while limited in their abilities to assess Allium consumption, indicate some associations of Allium vegetable consumption with decreased risk of cancer, particularly cancers of the gastrointestinal tract. Limited intervention studies have been conducted to support these associations. The majority… 

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References

SHOWING 1-10 OF 100 REFERENCES

A historical perspective on garlic and cancer.

Since garlic and its constituents can suppress carcinogen formation, carcinogen bioactivation, and tumor proliferation it is imperative that biomarkers be established to identify which individuals might benefit most and what intakes can occur with ill consequences.

Gastric Cancer and Allium Vegetable Intake: A Critical Review of the Experimental and Epidemiologic Evidence

A favorable role of high intakes of allium vegetables, mainly garlic and onion, in the etiology of gastric cancer is suggested and several limitations, including possible publication bias and the difficulty to establish a dose-risk relationship, suggest caution in the interpretation.

The analysis of onion and garlic.

  • V. Lanzotti
  • Medicine, Chemistry
    Journal of chromatography. A
  • 2006

Preclinical perspectives on garlic and cancer.

The ability of garlic and related allyl sulfur compounds to block tumors in the colon, lung, breast, and liver suggests general mechanisms that are not tissue specific, and additional studies are needed that incorporate transgenic and knockout models to assist in the identification of molecular targets for garlic and its associatedallyl sulfur components.

Onion and garlic use and human cancer.

This uniquely large data set from southern European populations shows an inverse association between the frequency of use of allium vegetables and the risk of several common cancers.

Molecular mechanisms and targets of cancer chemoprevention by garlic-derived bioactive compound diallyl trisulfide.

Health benefits of garlic and other Allium vegetables (e.g., onions), such as lipid lowering and anticancer effects, are credited to metabolic byproducts, including diallyl trisulfide (DATS).

Mechanisms by which garlic and allyl sulfur compounds suppress carcinogen bioactivation. Garlic and carcinogenesis.

  • J. Milner
  • Biology
    Advances in experimental medicine and biology
  • 2001
A host of studies provides compelling evidence that garlic and its organic allyl sulfur components are effective inhibitors of the cancer process and must be viewed as part of the entire diet, since several dietary constituents can influence the degree of protection.

Garlic: its anticarcinogenic and antitumorigenic properties.

Overall, several investigations indicate that garlic and its organic allyl sulfur components inhibit the cancer process and that the benefits of garlic are not limited to a specific species, a particular tissue, or a specific carcinogen.

The influence of heating on the anticancer properties of garlic.

It is suggested that heating destroyed garlic's active allyl sulfur compound formation, which may relate to its anticancer properties.
...