Garlic [Allium sativum]: a review of its potential use as an anti-cancer agent.

@article{Thomson2003GarlicS,
  title={Garlic [Allium sativum]: a review of its potential use as an anti-cancer agent.},
  author={Martha Thomson and Muslim Ali},
  journal={Current cancer drug targets},
  year={2003},
  volume={3 1},
  pages={
          67-81
        }
}
Garlic [Allium sativum] is among the oldest of all cultivated plants. It has been used as a medicinal agent for thousands of years. It is a remarkable plant, which has multiple beneficial effects such as antimicrobial, antithrombotic, hypolipidemic, antiarthritic, hypoglycemic and antitumor activity. In this review, we will discuss particularly the largely preclinical use of this agent in the treatment and prevention of cancer. A number of studies have demonstrated the chemopreventive activity… 

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References

SHOWING 1-10 OF 157 REFERENCES

The potential application of Allium sativum (garlic) for the treatment of bladder cancer.

Garlic and onions: their effect on eicosanoid metabolism and its clinical relevance.

Both garlic and onion have been shown to have applications as antimicrobial, antithrombotic, antitumor, hypolipidaemic, antiarthritic and hypoglycemic agents.

Initial study on naturally occurring products from traditional Chinese herbs and vegetables for chemoprevention

It is suggested that induction of apoptosis may contribute to the mechanisms of antitumor activity of elemene and allicin, which merit investigation as potential chemoprevention agents in humans.

Intake of garlic and its bioactive components.

The health benefits of garlic likely arise from a wide variety of components, possibly working synergistically, and ample research suggests that several bioavailable components likely contribute to the observed beneficial effects.

Cholesterol-lowering effect of garlic extracts and organosulfur compounds: human and animal studies.

The results of these studies indicate that the cholesterol-lowering effects of garlic extract, such as AGE, stem in part from inhibition of hepatic cholesterol synthesis by water-soluble sulfur compounds, especially SAC.

Garlic: a review of its relationship to malignant disease.

Allium sativum (garlic)--a natural antibiotic.

Therapeutic actions of garlic constituents

The epidemiological, clinical, and laboratory data have proved that garlic contains many biologically and pharmacologically important compounds, which are beneficial to human health from cardiovascular, neoplastic, and several other diseases.

Tumor inhibition by a sulfhydryl-blocking agent related to an active principle of garlic (Allium sativum).

Summary Extracts of garlic ( Allium sativum ) contain a bactericidal agent which is formed by the action of an enzyme on a substrate present in garlic bulbs. The active principle formed by this
...