Gargantulide A, a complex 52-membered macrolactone showing antibacterial activity from Streptomyces sp.

  title={Gargantulide A, a complex 52-membered macrolactone showing antibacterial activity from Streptomyces sp.},
  author={Jung-Rae Rho and Gurusamy Subramaniam and Hyukjae Choi and Eun-hee Kim and Sok Peng Ng and K. Yoganathan and Siewbee Ng and Antony D. Buss and Mark S. Butler and William H. Gerwick},
  journal={Organic letters},
  volume={17 6},
Gargantulide A (1), an extremely complex 52-membered macrolactone, was isolated from Streptomyces sp. A42983 and displayed moderate activity against MRSA. The planar structure of 1 was determined using 2D NMR, and its stereochemistry was partially established on the basis of NOESY correlations, J-based configuration analysis, and Kishi's universal NMR database. 

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