Gargantulide A, a complex 52-membered macrolactone showing antibacterial activity from Streptomyces sp.

@article{Rho2015GargantulideAA,
  title={Gargantulide A, a complex 52-membered macrolactone showing antibacterial activity from Streptomyces sp.},
  author={Jung-Rae Rho and Gurusamy Subramaniam and Hyukjae Choi and Eun-Hee Kim and Sok Peng Ng and Kanagasundaram Yoganathan and Siewbee Ng and Antony David Buss and Mark S Butler and William H Gerwick},
  journal={Organic letters},
  year={2015},
  volume={17 6},
  pages={
          1377-80
        }
}
Gargantulide A (1), an extremely complex 52-membered macrolactone, was isolated from Streptomyces sp. A42983 and displayed moderate activity against MRSA. The planar structure of 1 was determined using 2D NMR, and its stereochemistry was partially established on the basis of NOESY correlations, J-based configuration analysis, and Kishi's universal NMR database. 
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