Garcinol regulates EMT and Wnt signaling pathways in vitro and in vivo, leading to anticancer activity against breast cancer cells.

@article{Ahmad2012GarcinolRE,
  title={Garcinol regulates EMT and Wnt signaling pathways in vitro and in vivo, leading to anticancer activity against breast cancer cells.},
  author={Aamir Ahmad and Sanila H. Sarkar and Bassam Bitar and Shadan Ali and Amro Aboukameel and Seema Sethi and Yiwei Li and Bin Bao and Dejuan Kong and S Preeya Banerjee and Subhash Balkrishna Padhye and Fazlul H. Sarkar},
  journal={Molecular cancer therapeutics},
  year={2012},
  volume={11 10},
  pages={2193-201}
}
Anticancer properties of Garcinia indica-derived garcinol are just beginning to be elucidated. We have earlier reported its cancer cell-specific induction of apoptosis in breast cancer cells, which was mediated through the downregulation of NF-κB signaling pathway. To gain further mechanistic insight, here, we show for the first time that garcinol effectively reverses epithelial-to-mesenchymal transition (EMT), that is, it induces mesenchymal-to-epithelial transition (MET) in aggressive triple… CONTINUE READING

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  • AhmadA, AS Ali, S Ali, WangZ, KongD, Sarkar
  • New York: Nova Publishers;
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Role of novel nutraceuticals garcinol, plumbagin and mangiferin in the prevention and therapy of human malignancies: mechanisms of anticancer activity. In:Sarkar FH, editor. Nutraceuticals and cancer

  • A Ahmad, S Padhye, FH. Sarkar
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1 Excerpt

MicroRNAs : targets of interest in breast cancer research

  • AS Ali, S Ali, KongD WangZ, FH Sarkar
  • MicroRNA : expression , detection and therapeutic…
  • 2011

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