Garcinol-induced apoptosis in prostate and pancreatic cancer cells is mediated by NF- kappaB signaling.

@article{Ahmad2011GarcinolinducedAI,
  title={Garcinol-induced apoptosis in prostate and pancreatic cancer cells is mediated by NF- kappaB signaling.},
  author={Aamir Ahmad and Zhiwei Wang and Christine Wojewoda and R. Ali and D. Kong and M. Maitah and Sanjeev Banerjee and B. Bao and S. Padhye and F. Sarkar},
  journal={Frontiers in bioscience},
  year={2011},
  volume={3},
  pages={
          1483-92
        }
}
Garcinol, obtained from Garcinia indica, is a potent antioxidant. Its anticancer activity has been investigated; however, there is no published report on its action against prostate and pancreatic cancer cells. We have earlier reported its activity against breast cancer cells, and here we tested our hypothesis that garcinol could inhibit cell proliferation and induce apoptosis in prostate as well as pancreatic cancer cells. Using multiple techniques such as MTT, Histone-DNA ELISA, activated… Expand
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