Garcinia mangostana L.: a phytochemical and pharmacological review

@article{Obolskiy2009GarciniaML,
  title={Garcinia mangostana L.: a phytochemical and pharmacological review},
  author={D. Obolskiy and I. Pischel and N. Siriwatanametanon and M. Heinrich},
  journal={Phytotherapy Research},
  year={2009},
  volume={23}
}
Garcinia mangostana L. (mangosteen, Clusiaceae) has a long history of use as a medical plant, mostly in Southeast Asia. This is a review of the phytochemistry and pharmacology of mangosteen. Traditionally mangosteen is famous for its antiinflammatory properties and is used in the treatment of skin infections and wounds. Other applications include the therapy of various conditions such as dysentery, different urinary disorders, cystitis and gonorrhoea. This review highlights the development of… Expand
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References

SHOWING 1-10 OF 58 REFERENCES
ANTI-INFLAMMATORY AND ANALGESIC ACTIVITIES OF THE EXTRACT FROM GARCINIA MANGOSTANA LINN..
The anti-inflammatory activity of extracts from Garcinia mangostana Linn., Nyctanthes arbortristis Linn., Cyperus rotundus L. and Clinacanthus nutans (Burm.f.) Lindau were tested in mice usingExpand
Pharmacological profile of mangostin and its derivatives.
TLDR
Mangostin (M), a naturally occurring xanthone in the rinds of the fruits of Garcinia mangostana Linn, and its derivatives were screened for various pharmacological effects in experimental animals and none of the test compounds produced significant effects on the cardiovascular system of frogs and dogs. Expand
Anti-inflammatory activity of mangostins from Garcinia mangostana.
The fruit hull of Garcinia mangostana Linn (Guttiferae) is used as an anti-inflammatory drug in Southeast Asia. Two xanthones, alpha- and gamma-mangostins, were isolated from the fruit hull of G.Expand
Cytotoxic prenylated xanthones from the young fruit of Garcinia mangostana.
TLDR
Among the isolates, alpha-mangostin (12), the major metabolite, exhibited the most potent effects against the BC-1 cells, an activity greater than that of the standard drug ellipticine (IC50 = 1.46 microg/ml), while gartanin (10) displayed the strongest activity against the NCI-H187 cells at the respective IC50 values. Expand
Effect of Garcinia mangostana on inflammation caused by Propionibacterium acnes.
TLDR
Garcinia mangostana was highly effective in scavenging free radicals and was able to suppress the production of pro-inflammatory cytokines, which could be useful in treatment of acne vulgaris. Expand
Inhibitions of histamine release and prostaglandin E2 synthesis by mangosteen, a Thai medicinal plant.
TLDR
Results suggest that the 40% ethanol extract of mangosteen has potent inhibitory activities of both histamine release and prostaglandin E2 synthesis, which is used as a Thai indigenous medicine and as an anti-allergy crude drug in Japan. Expand
Immunopharmacological activity of polysaccharide from the pericarb of mangosteen garcinia: phagocytic intracellular killing activities.
TLDR
It is suggested that polysaccharides in the extract can stimulate phagocytic cells and kill intracellular bacteria (S. enteritidis) and both MDE3 and MDE4 stimulate superoxide production. Expand
Antimycobacterial activity of prenylated xanthones from the fruits of Garcinia mangostana.
TLDR
Tri- and tetra-oxygenated xanthones with di-C5 units or with a C5 and a modified C5 groups are essential for high activities and substitution in the A and C rings has been shown to modify the bioactivity of the compounds. Expand
Antimicrobial effects of Thai medicinal plants against acne-inducing bacteria.
TLDR
The data indicated that Garcinia mangostana had a strong inhibitory effect on Propionibacterium acnes and Staphylococcus epidermidis, and this plant would be an interesting topic for further study and possibly for an alternative treatment for acne. Expand
Antioxidant xanthones from the pericarp of Garcinia mangostana (Mangosteen).
TLDR
Except for compound 2, which was isolated as a minor component, the antioxidant activities of all isolates were determined using authentic and morpholinosydnonimine-derived peroxynitrite methods, and compounds 1, 8, 10, 11, and 13 were the most active. Expand
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