Garcinia cambogia Extract Ameliorates Visceral Adiposity in C57BL/6J Mice Fed on a High-Fat Diet

@article{Kim2008GarciniaCE,
  title={Garcinia cambogia Extract Ameliorates Visceral Adiposity in C57BL/6J Mice Fed on a High-Fat Diet},
  author={Keun-Young Kim and Hye-Nam Lee and Yun Jung Kim and Taesun Park},
  journal={Bioscience, Biotechnology, and Biochemistry},
  year={2008},
  volume={72},
  pages={1772 - 1780}
}
The aim of present study is to evaluate the effects of Garcinia cambogia on the mRNA levels of the various genes involved in adipogenesis, as well as on body weight gain, visceral fat accumulation, and other biochemical markers of obesity in obesity-prone C57BL/6J mice. Consumption of the Garcinia cambogia extract effectively lowered the body weight gain, visceral fat accumulation, blood and hepatic lipid concentrations, and plasma insulin and leptin levels in a high-fat diet (HFD)-induced… 
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Germacrone may help attenuate hyperlipidemia by suppressing FA synthesis and uptake by inhibiting SREBP signaling pathway activation and improve lipid metabolism by stimulating FA β-oxidation by activating the AMPKα signaling pathway in HFD-induced obesity.
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Installing Garcinia Cambogia extract along with high fat diet significantly decreased body weight gain, glucose intolerance, plasma leptin and TNF-α level and no significant changes were observed in the renal function parameters in any of the groups.
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Results indicate that Rapha diet® preparation could improve HFD-induced obesity by reducing both lipid accumulation and the size of adipocytes, and reversed the blood lipid levels and attenuated hepatic steatosis.
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Suggesting association between lipid peroxidation, obesity and nephropathy, while Garcinia ameliorated the damaging effects of the HFD or HSD and decreased feed intake, MDA level and decreased oxidative stress in renal tissues is suggested.
Garcinia cambogia Ameliorates Non-Alcoholic Fatty Liver Disease by Inhibiting Oxidative Stress-Mediated Steatosis and Apoptosis through NRF2-ARE Activation
TLDR
The therapeutic effects of G. cambogia inhibited HFD-induced steatosis and apoptosis and abrogated abnormalities in serum chemistry and were due to hydroxycitric acid (HCA).
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