Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial.

@article{Heymsfield1998GarciniaC,
  title={Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial.},
  author={Steven B. Heymsfield and David B. Allison and Joseph R. Vasselli and Angelo Pietrobelli and Debra Greenfield and Christopher Nu{\~n}ez},
  journal={JAMA},
  year={1998},
  volume={280 18},
  pages={
          1596-600
        }
}
CONTEXT Hydroxycitric acid, the active ingredient in the herbal compound Garcinia cambogia, competitively inhibits the extramitochondrial enzyme adenosine triphosphate-citrate (pro-3S)-lyase. [...] Key MethodDESIGN Twelve-week randomized, double-blind, placebo-controlled trial. SETTING Outpatient weight control research unit. PARTICIPANTS Overweight men and women subjects (mean body mass index [weight in kilograms divided by the square of height in meters], approximately 32 kg/m2). Expand
Effects of Long-term Administration of Garcinia cambogia extract on Visceral Fat Accumulation in Humans: A Placebo-controlled Double Blind Trial
TLDR
G. cambogia extract is useful for reducing body fat accumulation, especially visceralfat accumulation, in humans who are preobese or obese class 1. Expand
Effects of garcinia cambogia (Hydroxycitric Acid) on visceral fat accumulation: a double-blind, randomized, placebo-controlled trial.
TLDR
G cambogia reduced abdominal fat accumulation in subjects, regardless of sex, who had the visceral fat accumulation type of obesity, and it is expected that G c Cambogia may be useful for the prevention and reduction of accumulation of visceral fat. Expand
Evaluation of the pharmacotherapeutic efficacy of Garcinia cambogia plus Amorphophallus konjac for the treatment of obesity
TLDR
Evaluating the pharmacotherapeutic efficacy of standardized extracts of G. cambogia plus A. konjac in the treatment of obesity suggests that the treatment had a significant hypocholesterolemic effect, without influencing the anthropometric or calorimetric parameters tested. Expand
Hypolipemic Effect of Garcinia cambogia in Obese Women
TLDR
The short‐term treatment with G. cambogia demonstrated a hypotriglyceridemic effect, which does not appear to be related to changes in leptinemia, and no significant response was observed on other variables of the lipid profile, or on the anthropometric and calorimetric parameters. Expand
Evaluation of the Safety and Efficacy of Hydroxycitric Acid or Garcinia cambogia Extracts in Humans
TLDR
There is still little evidence to support the potential effectiveness and long-term benefits of G. cambogia extracts, and except in rare cases, studies conducted in experimental animals have not reported increased mortality or significant toxicity. Expand
Chapter 48 – Garcinia cambogia
TLDR
Results of some randomized, placebo-controlled human clinical trials either have not reported the same outcome or there has been marginal reduction in body weight on a short-term basis, not beyond 12 weeks, and G. cambogia should not be concurrently used with other drugs to circumvent drug interactions. Expand
Erratum: Antiobesity effect of Gynostemma pentaphyllum extract (actiponin): A randomized, double‐blind, placebo‐controlled trial
TLDR
It is suggested that actiponin supplementation may be effective for treating obese individuals and is a potent antiobesity reagent that does not produce any significant adverse effects. Expand
Does Glycine max leaves or Garcinia Cambogia promote weight-loss or lower plasma cholesterol in overweight individuals: a randomized control trial
TLDR
Ten weeks of EGML or GCE supplementation did not promote weight-loss or lower total cholesterol in overweight individuals consuming their habitual diet, although, EGML did increase plasma HDL-C levels which is associated with a lower risk of atherosclerosis. Expand
Effects of (−)-hydroxycitric acid on appetitive variables
TLDR
This study does not support a satiety effect of HCA, and the active treatment group did not exhibit better dietary compliance or significant correlations between appetitive variables and energy intake or weight change. Expand
A new class of phytonutrients for body weight management * SUMMARY
A botanical weight management formula (BWMF) composed of hydroxycitric acid (HCA), garcinol, diterpene forskolin and alkaloid piperine was developed. The composition of BWMF is aimed at overcomingExpand
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It was observed that inclusion of (−)hydroxycitrate in the diet resulted in significant reduction in food intake, body weight, epididymal fat and serum triglyceride in the animals and also decrease in the feed efficiency ratio. Expand
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This report addresses the use and abuse of appetite-suppressant drugs in the treatment of obesity with a focus on dinitrophenol, a drug that was noted to increase metabolism and to produce weight loss. Expand
Inhibition of lipogenesis in rat liver by (-)-hydroxycitrate.
TLDR
The in vivo rate of lipogenesis was markedly decreased for 150 min following the administration of (−)-hydroxycitrate either iv (0.017 mmoles/kg) or ip ( 0.0263 mmoles /kg) and fatty acid and cholesterol synthesis were significantly inhibited by the oral administration. Expand
(−)-Hydroxycitric acid—the principal acid in the fruits of Garcinia cambogia desr.
Abstract The principal acid in the highly acidic fruits of Garcinia cambogia has been identified as (−)-hydroxycitric acid. This acid has not been encountered in nature before. Fruits of two otherExpand
Factors that influence the outcome of placebo-controlled antidepressant clinical trials.
An important issue in judging the therapeutic potential of a new antidepressant drug is the effect size it generates in placebo-controlled trials which has to be compared with the effect of an activeExpand
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TLDR
Citrate is the major carrier in the transfer of acetyl groups from the mitochondrial matrix to the cytoplasm in the form of citrate, or of a closely related tricarboxylate. Expand
Pharmacotherapy in the management of obesity.
Although the article 1 on pharmacotherapy for obesity was an excellent review, 2 statements in that article deserve additional comment. First, the authors indicate, "The use of these medications wasExpand
Citrate and the conversion of carbohydrate into fat. Fatty acid synthesis by a combination of cytoplasm and mitochondria.
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It is concluded that citrate is the major carrier in the transfer of acetyl groups from the mitochondrial matrix to the cytoplasm during fatty acid synthesis. Expand
Gastrointestinal Surgery for Severe Obesity.
TLDR
A consensus panel recommended that patients seeking therapy for severe obesity for the first time should be considered for treatment in a nonsurgical program with integrated components of a dietary regimen, appropriate exercise, and behavioral modification and support. Expand
Effect of (-)-hydroxycitrate on fatty acid synthesis by rat liver in vivo.
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Abstract Incorporation of 3H from 3H2O was used to measure the rate of fatty acid synthesis in rat liver. (—)-Hydroxycitrate strongly inhibits fatty acid synthesis in vivo.
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