Garbage catastrophe theory of aging: imperfect removal of oxidative damage?

@article{Terman2001GarbageCT,
  title={Garbage catastrophe theory of aging: imperfect removal of oxidative damage?},
  author={Alexei Terman},
  journal={Redox report : communications in free radical research},
  year={2001},
  volume={6 1},
  pages={15-26}
}
  • Alexei Terman
  • Published 2001 in
    Redox report : communications in free radical…
Increasing evidence suggests an important role of oxidant-induced damage in the progress of senescent changes, providing support for the free radical theory of aging proposed by Harman in 1956. However, considering that biological organisms continuously renew their structures, it is not clear why oxidative damage should accumulate with age. No strong evidence has been provided in favor of the concept of aging as an accumulation of synthetic errors (e.g. Orgel's 'error-catastrophe' theory and… CONTINUE READING
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