Gap junctions relay FGF8-mediated right-sided repression of Nodal in rabbit.

Abstract

In vertebrate gastrula/neurula embryos, a cilia-driven leftward flow asymmetrically activates the Nodal cascade in the left lateral plate mesoderm (LPM). In frog embryos left-right axis formation was postulated to depend on gap junctions (GJs) during cleavage. Here, we show that GJs cooperate with fibroblast growth factor-8 (FGF8) to specify asymmetric… (More)
DOI: 10.1002/dvdy.21535

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