Gap junctions relay FGF8-mediated right-sided repression of Nodal in rabbit.

@article{Feistel2008GapJR,
  title={Gap junctions relay FGF8-mediated right-sided repression of Nodal in rabbit.},
  author={Kerstin Feistel and Martin Blum},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2008},
  volume={237 12},
  pages={
          3516-27
        }
}
  • Kerstin Feistel, Martin Blum
  • Published 2008
  • Medicine, Biology
  • Developmental dynamics : an official publication of the American Association of Anatomists
  • In vertebrate gastrula/neurula embryos, a cilia-driven leftward flow asymmetrically activates the Nodal cascade in the left lateral plate mesoderm (LPM). In frog embryos left-right axis formation was postulated to depend on gap junctions (GJs) during cleavage. Here, we show that GJs cooperate with fibroblast growth factor-8 (FGF8) to specify asymmetric Nodal in the rabbit embryo at gastrula/neurula. GJs and FGF signaling were manipulated in whole embryo and explant cultures of rabbit… CONTINUE READING

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