Gap junctions regulate extracellular signal-regulated kinase signaling to affect gene transcription.

@article{Stains2004GapJR,
  title={Gap junctions regulate extracellular signal-regulated kinase signaling to affect gene transcription.},
  author={Joseph P. Stains and Roberto Civitelli},
  journal={Molecular biology of the cell},
  year={2004},
  volume={16 1},
  pages={
          64-72
        }
}
Osteoblasts are highly coupled by gap junctions formed by connexin43. Overexpression of connexin45 in osteoblasts results in decreased chemical and electrical coupling and reduces gene transcription from connexin response elements (CxREs) in the osteocalcin and collagen Ialpha1 promoters. Here, we demonstrate that transcription from the gap junction-dependent osteocalcin CxRE is regulated by extracellular signal-regulated protein kinase (ERK) and phosphatidylinositol 3-kinase (PI3K) cascades… CONTINUE READING

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