Gap junctions in the ventral hippocampal-medial prefrontal pathway are involved in anxiety regulation.

@article{Schoenfeld2014GapJI,
  title={Gap junctions in the ventral hippocampal-medial prefrontal pathway are involved in anxiety regulation.},
  author={Timothy J. Schoenfeld and Alexander D Kloth and Brian Y Hsueh and Matthew B Runkle and Gary A. Kane and Samuel S-H Wang and Elizabeth Gould},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2014},
  volume={34 47},
  pages={
          15679-88
        }
}
Anxiety disorders are highly prevalent but little is known about their underlying mechanisms. Gap junctions exist in brain regions important for anxiety regulation, such as the ventral hippocampus (vHIP) and mPFC, but their functions in these areas have not been investigated. Using pharmacological blockade of neuronal gap junctions combined with electrophysiological recordings, we found that gap junctions play a role in theta rhythm in the vHIP and mPFC of adult mice. Bilateral infusion of… CONTINUE READING
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