Gap junctions in inherited human disease

  title={Gap junctions in inherited human disease},
  author={Georg Zoidl and Rolf Dermietzel},
  journal={Pfl{\"u}gers Archiv - European Journal of Physiology},
Gap junctions (GJ) provide direct intercellular communication. The structures underlying these cell junctions are membrane-associated channels composed of six integral membrane connexin (Cx) proteins, which can form communicating channels connecting the cytoplasms of adjacent cells. This provides coupled cells with a direct pathway for sharing ions, nutrients, or small metabolites to establish electrical coupling or balancing metabolites in various tissues. Genetic approaches have uncovered a… CONTINUE READING


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