Gap junctions contribute to astrocytic resistance against zinc toxicity.

Abstract

Astrocytic gap junctions have been implicated in the regulation of cell viability. High amounts of extracellular zinc, which is released during ischemia, seizure, and brain trauma, can be cytotoxic to astrocytes. We tested whether gap junction coupling between astrocytes plays an important role in modulating zinc toxicity in hippocampal astrocytes. Zinc… (More)
DOI: 10.1016/j.brainresbull.2011.08.011

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