Gap junctions between the supporting cells in some acoustico-vestibular receptors

  title={Gap junctions between the supporting cells in some acoustico-vestibular receptors},
  author={Kiyoshi Hama and K Saito},
  journal={Journal of Neurocytology},
SummaryExtensive gap junctions are found between the supporting cells in acoustico-vestibular receptors (saccular macula of the goldfish; ampullar crista, utricular macula and organ of Corti of the guinea pig). The fine structural details of these gap junctions were examined using lanthanum hydroxide staining and freeze-fracture replicas, as well as conventional thin sections. It was found in the lanthanum treated saccular macula of the goldfish that the gap junction globules consist of five or… 

Voltage Gating of Gap Junctions in Cochlear Supporting Cells: Evidence for Nonhomotypic Channels

Most gap junctional channels in the inner ear have asymmetric voltage gating, which is indicative of heterogeneous coupling and may result from heterotypic channels or possibly heteromeric configurations, which implies that single connexin gene mutations may affect the normal physiological function of gap junctions that are not limited to homotypic configurations.

Intracellular recordings from supporting cells in the guinea-pig cochlea: AC potentials.

Supporting cells and hair cells from the low-frequency region of the guinea-pig cochlea were studied in vivo using intracellular recording and horseradish peroxidase marking techniques to suggest the fundamental component of the support-cell response accrues from hair-cell-generated currents.

Gap junction systems in the rat vestibular labyrinth: immunohistochemical and ultrastructural analysis.

The distribution of gap junctions within the vestibular labyrinth was investigated using immunohistochemistry and transmission electron microscopy. Connexin26-like immunoreactivity was observed among

Gap junctions between sensory and supporting cells of the utricular and saccular maculae in Anolis carolinensis examined by transmission electron microscopy.

  • D. S. Zahm
  • Biology
    The American journal of anatomy
  • 1980
The larger numbers of junctional projections observed at some levels may indicate a zonular distribution within the neuroepithelia, but only on supracalyceal parts of hair cells in the utricular striola was a series of gap junctions found to be closely associated with the reticular lamina.

Morphological aspects of potassium flow in the semicircular canal ampulla of the pigeon.

It is likely that the different morphology of the ion transport pathways is related to the different flow levels of potassium ions expressed by the different levels of the so-called endocochlear potential and concomitant movement of other ions in the cochlea and SCCA.

Fine structure of the afferent synapse and gap junctions on the sensory hair cell in the saccular macula of goldfish: A freeze-fracture study

  • K. Hama
  • Biology
    Journal of neurocytology
  • 1980
Membrane specializations at the active zone of the afferent synapse in the saccular macula of goldfish are described, including those of the presynaptic membrane and the postsynaptic membrane, and small gap junctions are found between hair cells and adjacent supporting cells.

Gap junctions in the rat cochlea: immunohistochemical and ultrastructural analysis

The organization described here, together with a great deal of information from previous investigators, suggest that serially arranged gap junctions of both epithelial and connective tissue cells serve as the strucural basis for recycling endolymphatic potassium ions that pass through the sensory cells during the transduction process.

Gap Junction Organization in the Mammalian Cochlea

These studies elucidate gap junction functions in the cochlea and provide insight for understanding the pathogenesis of this common hereditary deafness induced by connexin mutations and functional studies of mutant channels that cause human deafness.

Gap Junctions and Cochlear Homeostasis

These studies elucidate gap junction functions in the cochlea and provide insight for understanding the pathogenesis of this common hereditary deafness induced by connexin mutations and functional studies of mutant channels that cause human deafness.




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The ultrastructure of low resistance junctions between segments of lateral giant fibers in crayfish is studied in sections from specimens fixed either by conventional methods or by


The fine structure and distribution of tight and gap junctions in epithelia of the rat pancreas, liver, adrenal cortex, epididymis, and duodenum, and in smooth muscle were examined in paraformaldehyde-glutaraldehyde-fixed, tracer-permeated, and freeze-fractured tissue preparations.

Connections between cells of the developing squid as revealed by electrophysiological methods.

The application of the nucleic acid homology technique to determine if SV40 enhancement acted at a step before or after Ad.

Permeability and Structure of Junctional Membranes at an Electrotonic Synapse

Electron microscopy after fixation in the presence of lanthanum hydroxide indicates that these synapses are "gap junctions" and that there is a network of channels continuous with extracellular space between apposed junctional membranes.

Receptor Potentials from Hair Cells of the Lateral Line

Intracellular recordings from hair cells in the tail lateral line of mudpuppy Necturus maculosus show receptor potentials less than 800 microvolts, peak to peak, from stimuli that are considered

Structure and function of intercellular junctions.

The ultrastructure of the nexus. A correlated thin-section and freeze-cleave study.

It is postulated that central hydrophilic channels may extend through the subunit assembly to provide a direct route for intercellular communication.