Gap junctional intercellular communication and cell proliferation during rat liver carcinogenesis.

@article{Yamasaki1993GapJI,
  title={Gap junctional intercellular communication and cell proliferation during rat liver carcinogenesis.},
  author={Hiroshi Yamasaki and Vladimir A Krutovskikh and Marc Mesnil and Amedeo Columbano and Hiroyuki Tsuda and Naoko Ito},
  journal={Environmental Health Perspectives},
  year={1993},
  volume={101},
  pages={191 - 197}
}
During multistage liver carcinogenesis, there is a sequential decrease in gap junctional intercellular communication (GJIC), associated with reduced expression of a major liver gap-junction protein (connexin 32). There are also several lines of evidence indicating that the induction of cell proliferation plays an important role during liver carcinogenesis. The relationship between GJIC and cell proliferation and their roles in liver carcinogenesis are not yet known. Results from various… CONTINUE READING