Gap junctional communication between vascular cells. Induction of connexin43 messenger RNA in macrophage foam cells of atherosclerotic lesions.

@article{Polacek1993GapJC,
  title={Gap junctional communication between vascular cells. Induction of connexin43 messenger RNA in macrophage foam cells of atherosclerotic lesions.},
  author={Denise Polacek and Ratneshwar Lal and M V Volin and Peter Francis Davies},
  journal={The American journal of pathology},
  year={1993},
  volume={142 2},
  pages={593-606}
}
The structure and function of blood vessels depend on the ability of vascular cells to receive and transduce signals and to communicate with each other. One means by which vascular cells have been shown to communicate is via gap junctions, specifically connexin43. In atherosclerosis, the normal physical patterns of communication are disrupted by the subendothelial infiltration and accumulation of blood monocytes, which in turn can differentiate into resident foam cells. In this paper we report… CONTINUE READING