Gap junction systems in the mammalian cochlea

@article{Kikuchi2000GapJS,
  title={Gap junction systems in the mammalian cochlea},
  author={Toshihiko Kikuchi and Robert S. Kimura and David L. Paul and Tomonori Takasaka and Joe C. Adams},
  journal={Brain Research Reviews},
  year={2000},
  volume={32},
  pages={163-166}
}

Gap Junction Organization in the Mammalian Cochlea

These studies elucidate gap junction functions in the cochlea and provide insight for understanding the pathogenesis of this common hereditary deafness induced by connexin mutations and functional studies of mutant channels that cause human deafness.

Gap Junctions and Cochlear Homeostasis

These studies elucidate gap junction functions in the cochlea and provide insight for understanding the pathogenesis of this common hereditary deafness induced by connexin mutations and functional studies of mutant channels that cause human deafness.

Potassium ion recycling pathway via gap junction systems in the mammalian cochlea and its interruption in hereditary nonsyndromic deafness

The association of sensorineural hearing loss with genetic disorders provides strong evidence for the necessity of gap junction systems for the normal functioning of the cochlea and mutations of connexin genes that result in human nonsyndromic deafness cause dysfunction of cochlear gap junctions.

Inner Ear Connexin Channels: Roles in Development and Maintenance of Cochlear Function.

  • F. Mammano
  • Biology
    Cold Spring Harbor perspectives in medicine
  • 2018
Reducing connexin 26 expression by Cre/loxP recombination in the inner ear of adult mice results in a decreased endocochlear potential, increased hearing thresholds, and loss of >90% of outer hair cells, indicating that this connexIn is essential for maintenance of cochlear function.

Connexins in the Inner Ear

This chapter summarizes current knowledge about the molecular and functional properties of inner ear gap junctions and the inner ear pathologies associated with connexin mutations.

Gap junctions and connexins in the inner ear: their roles in homeostasis and deafness

Despite recent advances, a better understanding of the complexity of gap-junctional communication in the inner ear and the structure–function relationships of connexin proteins is required for the development of mechanism-based treatments of Connexin-associated hearing loss.

Connexins and gap junctions in the inner ear – it’s not just about K+ recycling

The current knowledge about the molecular and functional properties of inner ear gap junctions, and about tissue pathologies associated with connexin mutations, is summarised.

Connexins and gap junctions in the inner ear – it’s not just about K+ recycling

The current knowledge about the molecular and functional properties of inner ear gap junctions, and about tissue pathologies associated with connexin mutations, is summarised.

Cell-cell junctions: a target of acoustic overstimulation in the sensory epithelium of the cochlea

This study employed graded dextran-FITC, a macromolecule tracer that is impermeable to the organ of Corti under physiological conditions, to evaluate the barrier function of cell junctions in normal and noise-traumatized cochlear sensory epithelia and revealed a general spatial correlation between the site of sensory cell damage and the sites of junction disruption.

Compartmentalized and Signal-Selective Gap Junctional Coupling in the Hearing Cochlea

Data are supportive of the appearance of signal-selective gap junctions around the onset of hearing, with specific properties required to support auditory function, and suggest that separate medial and lateral buffering compartments exist in the hearing cochlea, which are individually dedicated to the homeostasis of inner hair cells and outer hair cells.
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References

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Gap junction systems in the rat vestibular labyrinth: immunohistochemical and ultrastructural analysis.

The distribution of gap junctions within the vestibular labyrinth was investigated using immunohistochemistry and transmission electron microscopy. Connexin26-like immunoreactivity was observed among

Connexin 26 mutations in hereditary non-syndromic sensorineural deafness

To the authors' knowledge, this is the first nonsyndromic sensorineural autosomal deafness susceptibility gene to be identified, which implicates Cx26 as an important component of the human cochlea.

Immunohistochemical Localization of the Na-K-Cl Co-transporter (NKCC1) in the Gerbil Inner Ear

The co-expression of NKCC1 and Na,K-ATPase in highly specialized subpopulations of cochlear and vestibular fibrocytes provides further evidence for their role in recycling K+ leaked or effluxed through hair cells into perilymph back to endolymph, as postulated in current models of inner ear ion homeostasis.