Gap junction reduction in cardiomyocytes following transforming growth factor-beta treatment and Trypanosoma cruzi infection.

@article{Waghabi2009GapJR,
  title={Gap junction reduction in cardiomyocytes following transforming growth factor-beta treatment and Trypanosoma cruzi infection.},
  author={Mariana Caldas Waghabi and Robson Coutinho-Silva and Jean-Jacques Feige and Maria de Lourdes Higuchi and David K Becker and Geoffrey Burnstock and Tania Cremonini de Ara{\'u}jo-Jorge},
  journal={Memorias do Instituto Oswaldo Cruz},
  year={2009},
  volume={104 8},
  pages={1083-90}
}
Gap junction connexin-43 (Cx43) molecules are responsible for electrical impulse conduction in the heart and are affected by transforming growth factor-beta (TGF-beta). This cytokine increases during Trypanosoma cruzi infection, modulating fibrosis and the parasite cell cycle. We studied Cx43 expression in cardiomyocytes exposed or not to TGF-beta T. cruzi, or SB-431542, an inhibitor of TGF-beta receptor type I (ALK-5). Cx43 expression was also examined in hearts with dilated cardiopathy from… CONTINUE READING
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