Gap junction permeability between tenocytes within tendon fascicles is suppressed by tensile loading.

@article{Maeda2012GapJP,
  title={Gap junction permeability between tenocytes within tendon fascicles is suppressed by tensile loading.},
  author={Eijiro Maeda and Shangjun Ye and Wen Wang and Dan L. Bader and Martin M. Knight and David A Lee},
  journal={Biomechanics and modeling in mechanobiology},
  year={2012},
  volume={11 3-4},
  pages={
          439-47
        }
}
Gap junction communication is an essential component in the mechanosensitive response of tenocytes. However, little is known about direct mechanoregulation of gap junction turnover and permeability. The present study tests the hypothesis that mechanical loading alters gap junction communication between tenocyte within tendon fascicles. Viable tenocytes within rat tail tendon fasicles were labelled with calcein-AM and subjected to a fluorescent loss induced by photobleaching (FLIP) protocol. A… CONTINUE READING
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Mechano-regulation of gap junction communications between tendon cells is dependent on the magnitude of tensile strain.

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