Gap junction-mimetic peptides do work, but in unexpected ways.

@article{Dahl2007GapJP,
  title={Gap junction-mimetic peptides do work, but in unexpected ways.},
  author={Gerhard P. Dahl},
  journal={Cell communication & adhesion},
  year={2007},
  volume={14 6},
  pages={
          259-64
        }
}
Gap junction mimetic peptides containing sequences of the extracellular loops of connexins inhibit the de-novo formation of gap junction channels but do not impair the function of existing cell-cell channels. Recently, a flurry of publications appeared showing that such "GAP" peptides attenuate ATP release and/or surrogate measures of it. Although no direct effect on putative connexin "hemichannels" has ever been shown, the peptide effect has been used as diagnostic tool for demonstrating the… CONTINUE READING
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