Gap junction intercellular communications regulate NK cell activation and modulate NK cytotoxic capacity.

@article{Tittarelli2014GapJI,
  title={Gap junction intercellular communications regulate NK cell activation and modulate NK cytotoxic capacity.},
  author={Andr{\'e}s Tittarelli and Ariadna Mendoza-Naranjo and Marcela Sep{\'u}lveda Far{\'i}as and Israel Enrique Padilla Guerrero and Fumitaka Ihara and Erik Wennerberg and Sebastian Herrero Riquelme and Alejandra Gleisner and Alexis M Kalergis and Andreas Lundqvist and Mercedes Natalia L{\'o}pez and Benedict J Chambers and Flavio Salazar-Onfray},
  journal={Journal of immunology},
  year={2014},
  volume={192 3},
  pages={
          1313-9
        }
}
Gap junctions (GJs) mediate intercellular communication between adjacent cells. Previously, we showed that connexin 43 (Cx43), the main GJ protein in the immune system, mediates Ag transfer between human dendritic cells (DCs) and is recruited to the immunological synapse during T cell priming. This crosstalk contributed to T cell activation, intracellular Ca(2+) responses, and cytokine release. However, the role of GJs in NK cell activation by DCs and NK cell-mediated cytotoxicity against tumor… CONTINUE READING
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