Gap junction inhibitors reduce endothelium-dependent contractions in the aorta of spontaneously hypertensive rats.

@article{Tang2008GapJI,
  title={Gap junction inhibitors reduce endothelium-dependent contractions in the aorta of spontaneously hypertensive rats.},
  author={Eva H. C. Tang and Paul Michel Vanhoutte},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2008},
  volume={327 1},
  pages={
          148-53
        }
}
Experiments were designed to determine the effect of gap junction inhibitors on endothelium-dependent contractions. Isolated aortic rings of spontaneously hypertensive rats (SHR) were suspended in vitro for isometric force recording. The nonselective gap junction inhibitor, carbenoxolone, reduced endothelium-dependent contractions to acetylcholine and the calcium ionophore A23187 [5-methylamino-2-(2S,3R,5R,8S,9S)-3,5,9-trimethyl-2-(1-oxo-(1H-pyrrol-2-yl)propan-2-yl)-1,7-dioxaspiro-(5,5)undecan… CONTINUE READING
Highly Cited
This paper has 26 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

Intercellular mRNA trafficking via membrane nanotube-like extensions in mammalian cells

Proceedings of the National Academy of Sciences of the United States of America • 2017
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 38 references

Vascular gap junctions and implications for hypertension.

Clinical and experimental pharmacology & physiology • 2004
View 2 Excerpts
Highly Influenced