Gap junction gene expression in human seizure disorder.

  title={Gap junction gene expression in human seizure disorder.},
  author={Christian C. Naus and John F. Bechberger and David L. Paul},
  journal={Experimental neurology},
  volume={111 2},
Increased intercellular coupling has been implicated in contributing to the synchronization of discharges characteristic of epileptic foci. Using RNA blot analysis, the level of mRNA for the heart-type gap junction protein, connexin43, is shown to be elevated in samples of temporal lobe neocortex obtained at the time of surgical resection for intractable seizure disorder. Much lower levels of this mRNA are detectable in peritumoral temporal lobe tissue samples obtained during removal of… CONTINUE READING
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