Gap junction-dependent increases in smooth muscle cAMP underpin the EDHF phenomenon in rabbit arteries.

@article{Taylor2001GapJI,
  title={Gap junction-dependent increases in smooth muscle cAMP underpin the EDHF phenomenon in rabbit arteries.},
  author={Hannah J Taylor and Andrew T Chaytor and D. H. Edwards and Tudor M. Griffith},
  journal={Biochemical and biophysical research communications},
  year={2001},
  volume={283 3},
  pages={583-9}
}
We have investigated the role of cAMP in nitric oxide (NO)- and prostanoid-independent vascular relaxations evoked by acetylcholine (ACh) in isolated arteries and perfused ear preparations from the rabbit. These EDHF-type responses are shown to be associated with elevated cAMP levels specifically in smooth muscle and are attenuated by blocking adenylyl cyclase or protein kinase A (PKA). Relaxations are amplified by 3-isobutyl-1-methylxanthine, which prevents cAMP hydrolysis, while remaining… CONTINUE READING
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