Ganoderol B: a potent α-glucosidase inhibitor isolated from the fruiting body of Ganoderma lucidum.

@article{Fatmawati2011GanoderolBA,
  title={Ganoderol B: a potent α-glucosidase inhibitor isolated from the fruiting body of Ganoderma lucidum.},
  author={Sri Fatmawati and Kuniyoshi Shimizu and Ryuichiro Kondo},
  journal={Phytomedicine : international journal of phytotherapy and phytopharmacology},
  year={2011},
  volume={18 12},
  pages={1053-5}
}
α-Glucosidase inhibitor has considerable potential as a diabetes mellitus type 2 drug because it prevents the digestion of carbohydrates. The search for the constituents reducing α-glucosidase activity led to the finding of active compounds in the fruiting body of Ganoderma lucidum. The CHCl(3) extract of the fruiting body of G. lucidum was found to show inhibitory activity on α-glucosidase in vitro. The neutral fraction, with an IC(50) of 88.7 μg/ml, had stronger inhibition than a positive… CONTINUE READING