Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota

@inproceedings{Chang2015GanodermaLR,
  title={Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota},
  author={Chih-Jung Chang and Chuan-Sheng Lin and Chia-Chen Lu and J. C. Martel and Yun-Fei Ko and David M. Ojcius and Shun-Fu Tseng and Tsung-Ru Wu and Yi-Yuan Margaret Chen and J. Young and H C Lai},
  booktitle={Nature communications},
  year={2015}
}
Obesity is associated with low-grade chronic inflammation and intestinal dysbiosis. Ganoderma lucidum is a medicinal mushroom used in traditional Chinese medicine with putative anti-diabetic effects. Here, we show that a water extract of Ganoderma lucidum mycelium (WEGL) reduces body weight, inflammation and insulin resistance in mice fed a high-fat diet (HFD). Our data indicate that WEGL not only reverses HFD-induced gut dysbiosis-as indicated by the decreased Firmicutes-to-Bacteroidetes… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 130 references

Adaptor-mediated Lon proteolysis restricts Bacillus subtilis hyperflagellation.

Proceedings of the National Academy of Sciences of the United States of America • 2015

Crosstalk and the evolution of specificity in two-component signaling.

Proceedings of the National Academy of Sciences of the United States of America • 2014

Impact of the gut microbiota , prebiotics , and probiotics on human health and disease

A. M. Caricilli
Biomed . J . • 2014

Alterations of the gut microbiota in high - fat diet mice is strongly linked to oxidative stress

M. Million
Appl . Microbiol . Biotechnol . • 2013