Ganoderma lucidum polysaccharides prevent platelet-derived growth factor-stimulated smooth muscle cell proliferation in vitro and neointimal hyperplasia in the endothelial-denuded artery in vivo.

@article{Wang2012GanodermaLP,
  title={Ganoderma lucidum polysaccharides prevent platelet-derived growth factor-stimulated smooth muscle cell proliferation in vitro and neointimal hyperplasia in the endothelial-denuded artery in vivo.},
  author={Shu-Huei Wang and Chan-Jung Liang and Yu-Wen Weng and Yung-Hsiang Chen and H Hsu and H J Chien and J C Tsai and Ying-Chin Tseng and Chi-Yuan Li and Yuh-Lien Chen},
  journal={Journal of cellular physiology},
  year={2012},
  volume={227 8},
  pages={3063-71}
}
Ganoderma lucidum is used in traditional Chinese medicine to prevent or treat a variety of diseases, including cardiovascular disorders. We previously demonstrated that a glucan-containing extract of Reishi polysaccharides (EORP) has the potent anti-inflammatory action of reducing ICAM-1 expression in lipopolysaccharide (LPS)-treated human aortic smooth muscle cells (HASMCs) and LPS-treated mice. In the present study, we examined whether EORP inhibited platelet-derived growth factor-BB (PDGF… CONTINUE READING
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