Gankyrin: a new oncoprotein and regulator of pRb and p53.

  title={Gankyrin: a new oncoprotein and regulator of pRb and p53.},
  author={Simon P Dawson and Hiroaki Higashitsuji and Anthony James Wilkinson and Jun Fujita and Ruth J. Mayer},
  journal={Trends in cell biology},
  volume={16 5},
Gankyrin is a new oncoprotein with potent cell cycle and apoptotic properties that is overexpressed early in hepatocarcinogenesis and in hepatocellular carcinomas. Gankyrin regulates the phosphorylation of the retinoblastoma protein (pRb) by CDK4 and enhances the ubiquitylation of p53 by the RING ubiquitin ligase MDM2. Purified preparations of the 26S proteasome contain gankyrin, which specifically interacts with the S6b (Rpt3) ATPase of the 19S regulator. In conclusion, gankyrin is a small… CONTINUE READING


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