Gangliosides protect bowel in an infant model of necrotizing enterocolitis by suppressing proinflammatory signals.

@article{Schnabl2009GangliosidesPB,
  title={Gangliosides protect bowel in an infant model of necrotizing enterocolitis by suppressing proinflammatory signals.},
  author={Kareena Leanne Schnabl and Bodil Larsen and John E Van Aerde and Gordon Lees and Mark G. Evans and Miodrag Mike Belosevic and Catherine J Field and Alan Bryan Robert Thomson and Michael Thomas Clandinin},
  journal={Journal of pediatric gastroenterology and nutrition},
  year={2009},
  volume={49 4},
  pages={382-92}
}
OBJECTIVES Necrotizing enterocolitis (NEC) has high morbidity in premature infants. Hypoxia-ischemia, infection, and enteral feeding are risk factors associated with NEC, whereas feeding human milk is protective. Vasoactive and inflammatory mediators in NEC remain elusive. Gangliosides are found in human milk and enterocyte membranes. An infant bowel model of NEC was developed to test the hypothesis that gangliosides modulate the inflammatory response to infection and hypoxia. PATIENTS AND… CONTINUE READING

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