Gangliosides of the Vertebrate Nervous System.

  title={Gangliosides of the Vertebrate Nervous System.},
  author={Ronald L. Schnaar},
  journal={Journal of molecular biology},
  volume={428 16},
Gangliosides, sialylated glycosphingolipids, found on all vertebrate cells and tissues, are major molecular determinants on the surfaces of vertebrate nerve cells. Composed of a sialylated glycan attached to a ceramide lipid, the same four structures-GM1, GD1a, GD1b, and GT1b-represent the vast majority (>90%) of gangliosides in the brains of all mammals and birds. Primarily found on the outer surface of the plasma membrane with their glycans facing outward, gangliosides associate laterally… CONTINUE READING
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