Gangliosides inhibit the development from monocytes to dendritic cells.

  title={Gangliosides inhibit the development from monocytes to dendritic cells.},
  author={Matthias Woelfl and W Y Batten and Carsten Posovszky and H. Christian Bernhard and Frank Berthold},
  journal={Clinical and experimental immunology},
  volume={130 3},
Dendritic cell (DC) development and function is critical in the initiation phase of any antigen-specific immune response against tumours. Impaired function of DC is one explanation as to how tumours escape immunosurveillance. In the presence of various soluble tumour-related factors DC precursors lose their ability to differentiate into mature DC and to activate T cells. Gangliosides are glycosphingolipids shed by tumours of neuroectodermal origin such as melanoma and neuroblastoma. In this… CONTINUE READING
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