Gangliosides in the human brain development and aging.

  title={Gangliosides in the human brain development and aging.},
  author={Ivan Kra{\vc}un and H. Rosner and V Drnovsek and Zeljka Vukeli{\'c} and C Cosovi{\'c} and Milica Trbojevi{\'c}-{\vC}epe and Milovan Kubat},
  journal={Neurochemistry international},
  volume={20 3},
In this study, brain gangliosides in prenatal and postnatal human life were analyzed. Immunohistochemically, the presence of "c"-pathway of gangliosides (GQ1c) in embryonic brain was only recorded at 5 weeks of gestation. Biochemical results indicated a twofold increase in human cortex ganglioside concentration between 16 and 22 weeks of gestation. The increasing ganglioside concentration was based on an increasing GD1a ganglioside fraction in all regions analyzed except cerebellar cortex… CONTINUE READING
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