Gangliosides in cell recognition and membrane protein regulation.

  title={Gangliosides in cell recognition and membrane protein regulation.},
  author={Pablo H H Lopez and Ronald L. Schnaar},
  journal={Current opinion in structural biology},
  volume={19 5},
Gangliosides, sialic acid-bearing glycosphingolipids, are expressed on all vertebrate cells, and are the major glycans on nerve cells. They are anchored to the plasma membrane through their ceramide lipids with their varied glycans extending into the extracellular space. Through sugar-specific interactions with glycan-binding proteins on apposing cells, gangliosides function as receptors in cell-cell recognition, regulating natural killer cell cytotoxicity via Siglec-7, myelin-axon interactions… CONTINUE READING
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