Gangliosides have a functional role during rotavirus cell entry.

  title={Gangliosides have a functional role during rotavirus cell entry.},
  author={Miguel A. Mart{\'i}nez and Susana Gonz{\'a}lez L{\'o}pez and Carlos F Arias and Pavel I{\vs}a},
  journal={Journal of virology},
  volume={87 2},
Cell entry of rotaviruses is a complex process, which involves sequential interactions with several cell surface molecules. Among the molecules implicated are gangliosides, glycosphingolipids with one or more sialic acid (SA) residues. The role of gangliosides in rotavirus cell entry was studied by silencing the expression of two key enzymes involved in their biosynthesis--the UDP-glucose:ceramide glucosyltransferase (UGCG), which transfers a glucose molecule to ceramide to produce… CONTINUE READING
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