Gangliosides expressed on breast cancer cells are E-selectin ligands.

  title={Gangliosides expressed on breast cancer cells are E-selectin ligands.},
  author={Venktesh S. Shirure and Karissa A. Henson and Ronald L. Schnaar and Leonardo Nimrichter and Monica M. Burdick},
  journal={Biochemical and biophysical research communications},
  volume={406 3},
Cancer cell adhesion to vascular endothelium is a critical process in hematogenous metastasis. We hypothesized that breast cancer cells express ligands that bind under blood flow conditions to E-selectin expressed by endothelial cells. At a hemodynamic wall shear rate, BT-20 and MDA-MB-468 breast cancer cells adhered to cytokine-activated human umbilical cord vein endothelial cells (HUVECs) but not to anti-E-selectin monoclonal antibody treated HUVECs, demonstrating that adhesion was… CONTINUE READING


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