Gangliosides enhance KCl-induced Ca2+ influx and acetylcholine release in brain synaptosomes.

@article{Tanaka1997GangliosidesEK,
  title={Gangliosides enhance KCl-induced Ca2+ influx and acetylcholine release in brain synaptosomes.},
  author={Yasuhito Tanaka and Hatsue Waki and Kazuo Kon and Susumu Ando},
  journal={Neuroreport},
  year={1997},
  volume={8 9-10},
  pages={2203-7}
}
Effects of gangliosides GM1 and GQ1b on cholinergic synaptic functions were investigated using synaptosomes prepared from mouse brain cortices. Treatment of synaptosomes with GM1 and GQ1b increased high K(+)-evoked acetylcholine (ACh) release in a bell-shaped dose-dependent manner. The peaks of the effects were found to be at 1-5 microM for GM1 and 5-10 microM for GQ1b. ACh synthesis and the levels of ACh in synaptosomes were not affected by the ganglioside treatment. Both gangliosides enhanced… CONTINUE READING

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