Gangliosides are receptors for murine polyoma virus and SV40

  title={Gangliosides are receptors for murine polyoma virus and SV40},
  author={B. Tsai and J. Gilbert and T. Stehle and W. Lencer and T. Benjamin and T. Rapoport},
  journal={The EMBO Journal},
  • B. Tsai, J. Gilbert, +3 authors T. Rapoport
  • Published 2003
  • Biology, Medicine
  • The EMBO Journal
  • Polyoma virus (Py) and simian virus 40 (SV40) travel from the plasma membrane to the endoplasmic reticulum (ER) from where they enter the cytosol and then the nucleus to initiate infection. Here we demonstrate that specific gangliosides can serve as plasma membrane receptors for these viruses, GD1a and GT1b for Py and GM1 for SV40. Binding and flotation assays were used to show that addition of these gangliosides to phospholipid vesicles allowed specific binding of the respective viruses. The… CONTINUE READING
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