Gangliosides are essential in the protection of inflammation and neurodegeneration via maintenance of lipid rafts: elucidation by a series of ganglioside-deficient mutant mice.

@article{Ohmi2011GangliosidesAE,
  title={Gangliosides are essential in the protection of inflammation and neurodegeneration via maintenance of lipid rafts: elucidation by a series of ganglioside-deficient mutant mice.},
  author={Yuhsuke Ohmi and Orie Tajima and Yuki Ohkawa and Yoshio Yamauchi and Yasuo Sugiura and Koichi Furukawa},
  journal={Journal of neurochemistry},
  year={2011},
  volume={116 5},
  pages={926-35}
}
Gangliosides are considered to be involved in the maintenance and repair of nervous tissues. Recently, novel roles of gangliosides in the regulation of complement system were reported by us. In this study, we compared complement activation, inflammatory reaction and disruption of glycolipid-enriched microdomain (GEM)/rafts among various mutant mice of ganglioside synthases, i.e. GM2/GD2 synthase knockout (KO), GD3 synthase KO, double KO (DKO) of these two enzymes and wild type. Up-regulation of… CONTINUE READING
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