Gangliosides activate Trk receptors by inducing the release of neurotrophins.

  title={Gangliosides activate Trk receptors by inducing the release of neurotrophins.},
  author={Stuart J. Rabin and Alessia Bachis and Italo Mocchetti},
  journal={The Journal of biological chemistry},
  volume={277 51},
We used NIH-3T3 fibroblasts expressing the different Trk receptors to examine whether GM1 ganglioside and its semisynthetic derivative LIGA20 activate various neurotrophin receptors. GM1 induced autophosphorylation of TrkC more potently than TrkA or TrkB receptors. In contrast, LIGA20 activated TrkB tyrosine phosphorylation only. Therefore, Scatchard analysis was performed to determine whether GM1 binds to TrkC. GM1 failed to displace neurotrophin-3 binding, suggesting that this ganglioside… CONTINUE READING


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