Ganglioside stimulation of axonal sprouting in vitro.

@article{Roisen1981GangliosideSO,
  title={Ganglioside stimulation of axonal sprouting in vitro.},
  author={Fred J. Roisen and Harry Bartfeld and Robert G. Nagele and Glee Yorke},
  journal={Science},
  year={1981},
  volume={214 4520},
  pages={577-8}
}
Bovine brain gangliosides were applied to primary and established neuronal cultures to examine the role of gangliosides in neuronal development. Media containing gangliosides enhanced the degree of axonal elongation exhibited by sensory ganglia neurons and increased the length and number of Neuro-2a neuroblastoma cell processes. Ganglioside-supplemented media caused a twofold increase in ornithine decarboxylase activity in both culture systems. These experiments suggest that gangliosides… CONTINUE READING

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