Ganglioside GM3 can induce megakaryocytoid differentiation of human leukemia cell line K562 cells.

@article{Nakamura1991GangliosideGC,
  title={Ganglioside GM3 can induce megakaryocytoid differentiation of human leukemia cell line K562 cells.},
  author={Mari Nakamura and Keita Kirito and Junichi. Yamanoi and T Wainai and Hisao Nojiri and Masaki Saito},
  journal={Cancer research},
  year={1991},
  volume={51 7},
  pages={1940-5}
}
The role of acidic glycosphingolipids in cell growth and differentiation was investigated using the multipotent leukemia cell line K562. When GM3 was added to cell culture media, the growth of K562 cells was remarkably inhibited and the cells were shown to have megakaryocytoid morphology. Ultrastructural study demonstrated that K562 cells treated with GM3… CONTINUE READING