Ganglioside GM1 protection from apoptosis of rat heart fibroblasts.

  title={Ganglioside GM1 protection from apoptosis of rat heart fibroblasts.},
  author={Lucia Cavallini and R Venerando and Giovanni Miotto and Adolfo Alexandre},
  journal={Archives of biochemistry and biophysics},
  volume={370 2},
Ceramide is involved as a mediator of apoptosis induced by a variety of signaling molecules or stressful events. Ceramide-derived sphingosine 1-phosphate behaves as an antiapoptotic agent. The ganglioside GM1 is known to protect neuronal cell lines from apoptosis induced by serum/growth factor withdrawal and its effect is mediated in part by the direct activation of the trkA NGF receptor [G. Ferrari et al. (1995) J. Biol. Chem. 270, 3074-3080]. We show that GM1, similarly to sphingosine 1… CONTINUE READING
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