Ganglioside GM(1a) on the cell surface is involved in the infection by human rotavirus KUN and MO strains.

@article{Guo1999GangliosideGO,
  title={Ganglioside GM(1a) on the cell surface is involved in the infection by human rotavirus KUN and MO strains.},
  author={Chao-tan Guo and Osamu Nakagomi and Mayumi Mochizuki and Hajime Ishida and Makoto Kiso and Yui Ohta and Takashi Suzuki and Daisei Miyamoto and Kazuya I. P. J. Hidari and Yasuo Suzuki},
  journal={Journal of biochemistry},
  year={1999},
  volume={126 4},
  pages={683-8}
}
Rotavirus is the most common cause of severe gastroenteritis in infants and children worldwide. The cell attachment of most animal rotaviruses, which belong to the neuraminidase-sensitive strains, requires sialic acid residues on the host cell membranes. On the other hand, most human rotaviruses are classified as neuraminidase-insensitive strains. The involvement of gangliosides on the host cell surface in human rotavirus infection was investigated by immunostaining analysis of target cells… CONTINUE READING

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