Ganglioside GD2-specific trifunctional surrogate antibody Surek demonstrates therapeutic activity in a mouse melanoma model

@inproceedings{Ruf2012GangliosideGT,
  title={Ganglioside GD2-specific trifunctional surrogate antibody Surek demonstrates therapeutic activity in a mouse melanoma model},
  author={Peter Ruf and Beatrix Sch{\"a}fer and Nina Eissler and Ralph Mocikat and J{\"u}rgen Hess and Matthias Pl{\"o}scher and Susanne Wosch and Ivonne Suckstorff and Christine Zehetmeier and Horst Lindhofer},
  booktitle={Journal of Translational Medicine},
  year={2012}
}
Trifunctional bispecific antibodies (trAb) are a special class of bispecific molecules recruiting and activating T cells and accessory immune cells simultaneously at the targeted tumor. The new trAb Ektomab that targets the melanoma-associated ganglioside antigen GD2 and the signaling molecule human CD3 (hCD3) on T cells demonstrated potent T-cell activation and tumor cell destruction in vitro. However, the relatively low affinity for the GD2 antigen raised the question of its therapeutic… CONTINUE READING
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Trifunctional Triomab antibodies for cancer therapy

  • H Lindhofer, J Hess, P Ruf
  • In Bispecific Antibodies. Edited by Kontermann RE…
  • 2011
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