Ganglioside GD1a restores infectibility to mouse cells lacking functional receptors for polyomavirus.

@article{Gilbert2005GangliosideGR,
  title={Ganglioside GD1a restores infectibility to mouse cells lacking functional receptors for polyomavirus.},
  author={Joanna M Gilbert and Jean S Dahl and Cathy Riney and John M. You and Cunqi Cui and Randall K. Holmes and Wayne I Lencer and Thomas L. Benjamin},
  journal={Journal of virology},
  year={2005},
  volume={79 1},
  pages={615-8}
}
Recent investigations on the pathway of cell entry by polyomavirus (Py) and simian virus 40 (SV40) have defined specific gangliosides as functional receptors mediating virus binding and transport from the plasma membrane to the endoplasmic reticulum (B. Tsai et al., EMBO J. 22:4346-4355, 2003; Gilbert and Benjamin, in press). These studies were carried out with C6 rat glioma cells, a heterologous host chosen for its known deficiency in ganglioside biosynthesis. Here, a cell genetic approach was… CONTINUE READING